S3 Daily Sensitive Toothpaste frozen in an ice block S3 Daily Sensitive Toothpaste frozen in an ice block

A patent-pending breakthrough

The three things
sensitive teeth need.
In one formula.

Three clinically-backed actives, engineered into one daily formula for sensitive teeth.

Calms Soothes exposed nerves
Strengthens Rebuilds weakened enamel
Protects Seals against triggers
Find your relief
87% Felt results within 7 days
+120 CLINICALLY BACKED STUDIES
100% TUBULE COVERAGE, PREVENTING SENSITIVE TRIGGERS
3x more calcium vs market leader

works from the first brush

Results you can see. And feel.

S3 Sensitivity Science™ better repairs microscopic damage vs the market leading sensitive brand.

before and after treatment S3 vs. market-leading toothpaste · before and after treatment
The market
leader
Independently tested at the University of Reading
Dentine tubule coverage after treatment
Market leader 84%
S3 daily 100%
S3 Daily Sensitive Toothpaste
S3 Daily Sensitive Toothpaste
Calms · Strengthens · Protects

Tubules are microscopic channels in the tooth that let fluid reach the nerve — the path a cold or sweet twinge travels. Seal them and the signal has nowhere to go.

¹University of Reading (2026). Scanning electron micrographs of dentine specimens from the leading competitor and S3 Sensitivity Science™.

Created by
the best in the field.

Mick Cox

“Having spent over a decade in the sensitivity category, I have seen first hand how incremental the innovation has been. With S3, I have set out to deliver a step change for patients and consumers.”

Mick Cox

Co-Founder

10+ years at Sensodyne

Majedeh Mazrai

“S3 Repair Technology™ is the first of its kind. It took over 3 years to develop, but finally we created something that the category has been missing for decades: a genuinely holistic approach to sensitivity.”

Majedeh Mazrai

Founding Scientist

Ex Sensodyne & Aquafresh

Dr Surina Sehgal

“I recommend S3 to patients for the most complete sensitive care. The multi-mechanism approach addresses what is actually happening in the tooth, and the results reflect that.”

Dr Surina Sehgal

Founding Dentist

Leading UK Dentist

Dr Victoria Sampson

“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”

Dr Victoria Sampson

Founding Dentist

Leading UK Dentist

There's a reason nothing has worked for you.

Sensitive teeth need three things, but regular toothpastes only fix a third of the problem.

S3 is the first toothpaste to deliver them all.

Calms + Strengthens + Protects

Sensitivity targets Targets
Regular sensitive brand Regular sensitive brand
CALMS
CALMS
CALMS
STRENGTHENS
STRENGTHENS
PROTECTS
PROTECTS
Actions delivered
3 of 3
1 of 3

75% do not get complete relief from today's sensitivity products.

Clinically proven

The first complete daily sensitive toothpaste.

  • Powered by S3 Repair Technology™
  • Starts working from the first brush
  • 30 day money-back guarantee

clinically backed ingredients

87% see results in 7 days

30 day money-back guarantee

The right toothpaste can change your life

Exclusively tested, and approved, by people with sensitivity.

"Tried Sensodyne, Pronamel, Regenerate. S3 is the first one that has made a real difference. Cold drinks are no longer something I think twice about."
Ben C. Cambridge
Verified Purchase
"After trying everything I didn't expect much but the difference is amazing. Not having to think about my sensitivity every day has made such a difference."
Anna R. London
Verified Purchase
"I always used to put off hygienist appointments because of the pain but S3 has stopped that. She also said my enamel is so much stronger after just 4 weeks!"
Sophie L. Oxford
Verified Purchase
"S3 has made such a difference to my life. I have receding gums so my sensitivity is really bad, but S3 has completely solved that! Love the gentle mint flavour too."
Marcus T. Bristol
Verified Purchase

Your questions, answered

S3 Daily Sensitive Toothpaste is the only toothpaste to contain S3 Repair Technology™, a unique technology that combines the three things that sensitive teeth need – all in a single formula.

Yes. The ingredients behind our patent-pending S3 Repair Technology™ have been backed by over 120+ clinical trials and reviews.

87% of existing sensitive toothpaste users feel an improvement within 7 days. For some, it can be much quicker. The compounding effect of daily brushing with S3 continues to develop over 2-3 months.

Clinically active ingredients:
Nano-Hydroxyapatite, Biomimetic Hydroxyapatite, Potassium Nitrate, Fluoride, Xylitol.

Full ingredient list:
Glycerin, Sorbitol, Hydrated Silica, Aqua, Hydroxyapatite, Potassium Nitrate, Xylitol, Hydroxyapatite (nano), Sodium Monofluorophosphate ,
Poloxamer 407, Sodium Lauroyl Sarcosinate , Aroma, Xanthan Gum, Potassium Chloride, Cocamidopropyl Betaine, Carageenan, Phenylpropanol, o-Cymen-5-ol,
Decylene Glycol, Sodium Saccharin, Titanium Dioxide, Potassium Hydroxide, Menthol, Anethole, Mentha Piperita Oil, Limonene, Citrus Limon Peel Oil.

Thanks to S3's remineralising, strengthening and daily protective properties; the daily use toothpaste continues to compound over time to lead to long-term healthier and stronger teeth.

Your subscription is for one single tube of S3 Daily Sensitive Toothpaste (£19.99). Your plan can be paused, rescheduled or cancelled at any time in your account.

By default your frequency will be set to 4 weeks, which can also be amended in your account.

Yes, all of our formulations are proudly formulated vegan & cruelty free.

We're confident that you'll be glad that you've made the switch to S3. If you have not felt the benefits after 21 days of daily brushing, get in touch with the team and we'd be happy to support.

We know that you can live with sensitivity.

But we also know that you would rather not.